Bicaudal C is required for the function of the follicular epithelium during oogenesis in Rhodnius prolixus

The morphology and physiology of the oogenesis have been well studied in vector Chagas disease Rhodnius prolixus. However, molecular interactions that regulate process egg formation, key for reproductive cycle vector, is still largely unknown. In order to understand cellular basis oogenesis, we examined function gene Bicaudal C (BicC) during early development R. We show prolixus BicC (Rp-BicC) expressed germarium, with cytoplasmic distribution, as follicular epithelium developing oocytes. RNAi silencing Rp-BicC resulted sterile females lay few, small, non-viable eggs. ovaries are reduced size a disarray epithelium. This indicates has central role regulation oogenesis. Although cells able form chorion, uptake vitelline by oocytes compromised. evidence polarity endocytic pathway, which crucial proper yolk deposition, affected. study provides insights into mechanisms underlying oocyte important de developmental and, therefore, player reproduction this insect.